Isesaki is located in the midst of the major cities in the Gunma Prefecture, and is one of Japan's most important industrial cities.

Isesaki first developed as a textile city, and is well known for "Isesaki-meisen," or silk cloth used to make kimonos. Since 1985, heavy industry has replaced this. As it moves into more of an urban area, Isesaki is focusing on industries such as domestic electric appliances, transportation vehicles, and the food industry.

"Peace of mind" is the objective in Isesaki, and the City has heavy emphasis on the services of welfare, public security, and health.

Isesaki is a nuclear weapon-free City, by a 1986 Declaration.

A Culture Hall was opened in 1981 to encourage interest in cultural matters.